108293-08-9Relevant academic research and scientific papers
Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery
Pokholenko, Oleksandr,Gissot, Arnaud,Vialet, Brune,Bathany, Katell,Thiery, Alain,Barthelemy, Philippe
, p. 5329 - 5334 (2013)
We report Lipid OligoNucleotide conjugates (LONs) bearing either two or three hydrophobic chains. LONs self-assemble into micellar aggregates, which provide a suitable reservoir for hydrophobic drugs such as paclitaxel. Our results demonstrate that the composition of the LONs both in terms of the lipid and the oligonucleotide sequence impacts their ability to host lipophilic molecules. Interestingly, binding of the complementary oligonucleotide selectively induces the release of part of the drug payload of the aggregates. These LON based micelles, which efficiently host hydrophobic drugs, represent an original stimuli-responsive drug delivery system. The Royal Society of Chemistry 2013.
COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
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Page/Page column 325, (2017/07/18)
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
HYDROPHOBICALLY MODIFIED ANTISENSE OLIGONUCLEOTIDES COMPRISING A TRIPLE ALKYL CHAIN
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Page/Page column 22, (2015/01/06)
The present invention concerns an oligonucleotide modified by substitution at the 3' or the 5' end by a moiety comprising at least three saturated or unsaturated, linear or branched hydrocarbon chains comprising from 2 to 30 carbon atoms, and the use therefore as a medicament, in particular for use for treating cancer.
The Synthesis and Langmuir-Blodgett Film Formation of Branched Fatty Acids with Two Long Alkyl Chains
Naito, K.,Egusa, S.
, p. 51 - 60 (2007/10/02)
Three kinds of branched fatty acids with two long alkyl chains were synthesized: 2-octadecyleicosanoic acid (I), 3-heptadecyleicosanoic acid (II), and 3,5-dioctadecyloxybenzoic acid (III).The structure assignments were confirmed by IR, 1H-NMR and and elem
Oxidative Coupling of Carboxylic Acid Dianions: The Total Synthesis of (+/-)-Hinokinin and (+/-)-Fomentaric Acid
Belletire, John L.,Fry, Douglas F.
, p. 2549 - 2555 (2007/10/02)
The oxidative coupling of carboxylic acid dianion derivatives provides the key intermediates needed for efficient syntheses of the symmetrical lignan hinokinin (9) and the unsymmetrical fungal metabolite fomentaric acid (22).Racemic hinokinin (9), a targed chosen to test the facility of dianion oxidative coupling in the presence of electron-rich aromatic rings, is prepared in an overall conversion of 61 percent from 3,4-(methylenedioxy)hydrocynnamic acid.Racemic fomentaric acid (22), a trisubstituted succinic acid derivative, results from a straightforward two-stepsequence that proceeds in an overall yield of 40 percent from eicosanoic acid.Preliminary studies demonstrate the utility of oxidative coupling in the synthesis of novel surfactant prototypes.
