1082949-67-4

Basic information

• Product Name: LY2584702
• Synonyms: LY2584702;LY-2584702 (free base);LY2584702 TsOH;4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo
• CAS NO: 1082949-67-4
• Molecular Formula: C₂₁H₁₉F₄N₇
• Molecular Weight: 445.43
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 1082949-67-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: RT (des.)
• Solubility: Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
• CAS DataBase Reference: LY2584702(CAS DataBase Reference)
• NIST Chemistry Reference: LY2584702(1082949-67-4)
• EPA Substance Registry System: LY2584702(1082949-67-4)

Safety Data

• Hazardous Substances Data: 1082949-67-4(Hazardous Substances Data)

Usage

Description

LYS6K2 (1082949-67-4) is a selective inhibitor of the p70 ribosomal S6 kinase (S6K).1 Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 μM with no activity at GSK3β and Erk1/2 at 10 μM.2?LYS6K2 is a useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K.2?Cell permeable.

Uses

LY 2584702 is an orally available inhibitor of p70S6K signalling and potential antineoplastic activity. Used in combination with Erlotinib or Everolimus as an anti-tumor treatment.

References

1) Fenton et al. (2011), Functions and regulation of the 70kDa ribosomal S6 kinases; Int. J. Biochem. Cell Biol., 43 47 2) Li et al. (2010), Bifurcation of insulin signaling pathway in the rat liver: mTORC1 required for stimulation of lipogenesis, but no inhibition of gluconeogenesis; Proc. Natl. Acad. Sci. USA 107 3441

Upstream product

• 1082950-60-4 tert-butyl 4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate 
• 5399-92-8 4-chloro-1H-pyrazolo[3,4-d]pyrimidine 

Downstream Products

• 1082949-68-5 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate 
• 1082948-81-9 4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine hydrochloride 

Relevant articles and documents

P70 S6 KINASE INHIBITORS

The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use.