108298-35-7

Upstream product

• 672-89-9 4-methoxy-6-methyl-2H-pyran-2-one 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 53119-56-5 3-methoxy-5-methylthiophene 

Downstream Products

• 249890-12-8 C₁₀H₁₄O₃ 
• 118718-71-1 Methyl 2-amino-4-methoxy-6-methylbenzoate 
• 118718-72-2 Methyl 2-(3-isopropylureido)-4-methoxy-6-methylbenzoate 
• 116913-61-2 Methyl 2-ethoxycarbonylamino-4-methoxy-6-methylbenzoate 
• 118730-25-9 2-Isocyanato-4-methoxy-6-methyl-benzoic acid methyl ester 
• 249890-05-9 C₁₀H₁₃O₂Cl 
• 116913-58-7 2-(methoxycarbonyl)-5-methoxy-3-methylbenzoic acid 

Relevant academic research and scientific papers

Photo-Cycloaddition Reactions of 2-Pyrones

Sensitized photoreactions of two 2-pyrones with five unsaturated compounds were investigated.The reactions of 2-pyrones with electron-deficient ethylenes gave cycloadducts (3) and cycloadducts (4) across the C5-C6 double bonds in the 2-pyrones.O

Studies on Antibiotics Active against Resistant Bacteria. Total Synthesis of MRSA-Active Tetarimycin A and Its Analogues

Making use of the Hauser-Kraus annulation as a key step, the first total synthesis of tetarimycin A has been accomplished in a highly convergent and operationally simple manner. Preliminary SAR not only validated that tetarimycin A exhibited potent activi

SERINE HYDROLASE INHIBITORS

Provided herein are benzoxazinone compounds of formula (I) and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.

SUBSTITUTED DIHYDRO-ISOINDOLONES USEFUL IN TREATING KINASE DISORDERS

The present invention is directed to novel substituted dihydro-isoindolone compounds of formula (I): and forms thereof, wherein Ring A, X3, R1, R2, R3, R4 and R6 are as herein defined, and their synthesis and use as protein kinase inhibitors and interactions thereof.

Synthesis of the proposed structure of fudecalone, an anticoccidial drimane terpenoid.

[formula: see text] The proposed structure of fudecalone (1), an anticoccidial drimane sesquiterpene, was synthesized as a racemate in six steps starting from a known phthalide (5). Interestingly, our synthetic 1 showed conformation 1b, while the natural

Diels-Alder reaction of methoxythiophenes: A new one-pot synthesis of dimethyl phthalates

A series of dimethyl phthalates have been prepared from methoxythiophenes and dimethyl acetylenedicarboxylate (DMAD) in xylene. When the reaction is carried out in acetic acid, thienylfumarates are obtained.

4-Alkoxy-6-alkyl-2-pyrones as Precursors for 4-Alkoxy-6-alkyl-2-aminobenzoic Acid Derivatives

4-Alkoxy-6-alkyl-2-pyrones undergo Diels-Alder reaction with dimethyl acetylenedicarboxylate to give dimethyl 4-alkoxy-6-alkylphthalates, which can be converted into 4-alkoxy-6-alkyl-2-aminobenzoic esters via a simple two-step sequence.

Syntheses of Highly Substituted Benzenes via Diels-Alder Reactions with 2H-Pyran-2-ones

The 2H-pyran-2-ones (α-pyrones) 1 react as dienes in Diels-Alder reactions with acetylene derivatives.The primarely formed cycloadducts immediately aromatize to benzenes by CO2 elimination.Thus, methyl acetylenedicarboxylate (2a) gives dimethyl phthalates 3, and methyl acetylenediphosphonate (2b) gives dimethyl 1,2-phenylenediphosphonates 8.The reactions of 1-(dimethylamino)-1-methoxyethene (9) with 1 regioselectively produce N,N-dimethylanilines 10 and isomeric homophthalate derivatives 12.Naphthoquinones 14 could be generated from 1,4-benzoquinone (13) and 1 in the presence of acetic anhydride and Pd/C.Hydroxy-2H-pyran-2-ones 4 react via their trimethylsilyl ether 6 analogously with 2a to give dimethyl (trimethylsiloxy)phthalates 7 which are easily converted to phenols 5 by acid-catalyzed hydrolysis.