1083002-07-6Relevant academic research and scientific papers
New functionalized 1,2,4-trioxepanes: Synthesis and antimalarial activity against multi-drug resistant P. yoelii in mice
Singh, Chandan,Pandey, Shilpi,Kushwaha, Ambuj K.,Puri, Sunil K.
scheme or table, p. 5190 - 5193 (2009/05/07)
A series of new amino functionalized 1,2,4-trioxepanes 8-16 and ester functionalized 1,2,4-trioxepanes 17-19 have been synthesized and evaluated against multi-drug resistant Plasmodium yoelii in Swiss mice. Amino functionalized trioxepanes 14, the most active compound of the series, showed 100% clearance of parasitaemia by oral route on day 4 and 75% protection to the treated mice beyond day 28.
