1083005-70-2Relevant academic research and scientific papers
Synthesis of (-)-(Z)-deoxypukalide
Donohoe, Timothy J.,Ironmonger, Alan,Kershaw, Neil M.
, p. 7314 - 7316 (2008)
(Chemical Equation Presented) Closing the deal: A ring-closing metathesis (RCM)/aromatization protocol, followed by a regioselective Negishi cross-coupling reaction and macrolactonization, with subsequent RCM mediate the synthesis of (-)-(Z)-deoxypukalide in 12 linear steps and 15% overall yield (see retrosynthesis; TBS=tert-butyldimethylsilyl, TIPS=triisopropylsilyl).
