1083057-14-0

Basic information

• Product Name: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester
• Synonyms: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester;tert-Butyl 3-(6-aMino-3-Methylpyridin-2-yl)benzoate;Benzoic acid, 3-(6-aMino-3-Methyl-2-pyridinyl)-, 1,1-diMethylethyl ester;EOS-61004
• CAS NO: 1083057-14-0
• Molecular Formula: C₁₇H₂₀N₂O₂
• Molecular Weight: 284.3529
• Mol File: 1083057-14-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 439.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.119±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.95±0.34(Predicted)
• CAS DataBase Reference: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester(1083057-14-0)
• EPA Substance Registry System: 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester(1083057-14-0)

Safety Data

• Hazardous Substances Data: 1083057-14-0(Hazardous Substances Data)

Usage

General Description

3-(6-Amino-3-methyl-pyridin-2-yl)-benzoic acid tert-butyl ester is a chemical compound with the molecular formula C18H21N3O2. It is a tert-butyl ester derivative of benzoic acid with an additional 3-(6-Amino-3-methyl-pyridin-2-yl) group. 3-(6-Amino-3-methyl-pyridin-2-yl)-benzoicacidtert-butylester is commonly used in the field of medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. It has also been studied for its potential biological activities, including its anti-inflammatory and anti-cancer properties. The tert-butyl ester group provides stability and solubility to the compound, making it easier to handle and utilize in chemical reactions.

Upstream product

• 1083057-13-9 tert-butyl 3-(3-methyl-1-oxo-1λ-pyridin-2-yl)benzoate 
• 7143-01-3 Methanesulfonic anhydride 
• 141-43-5 ethanolamine 
• 220210-56-0 3-(tert-butoxycarbonyl)phenylboronic acid 
• 1083057-12-8 tert-butyl 3-(3-methylpyridin-2-yl)benzoate 
• 3430-17-9 2-bromo-3-picoline 

Downstream Products

• 1160221-25-9 tert-butyl 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoate 
• 1160221-26-0 Lumacaftor hydrochloride 
• 936727-05-8 Lumacaftor 

Relevant articles and documents

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

This application describes methods of treating cystic fibrosis or a CFTR mediated disease comprising administering Compound I or a pharmaceutically acceptable salt thereof. (I) The application also describes pharmaceutical compositions comprising Compound I or a pharmaceutically acceptable salt thereof and optionally comprising one or more additional CFTR modulating agents.

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

Compound I of the formula (I) and/or pharmaceutically acceptable salt(s) of Compound I comprised in a pharmaceutical composition and methods of using the same to treat cystic fibrosis.

PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL)BENZOIC ACID AND ADMINISTRATION THEREOF

A pharmaceutical composition comprising Compound 1,(3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a diluent, a disintegrant, a surfactant, a binder, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering an oral pharmaceutical formulation of Compound 1 to the patient.