1083162-61-1 Usage
Description
FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1? FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2
Biochem/physiol Actions
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.
References
Shimada et al. (2016), Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis; Chem. Biol. 12 497
Zhang et al. (2021), FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma; Cancer 12 6610
Check Digit Verification of cas no
The CAS Registry Mumber 1083162-61-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,3,1,6 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1083162-61:
(9*1)+(8*0)+(7*8)+(6*3)+(5*1)+(4*6)+(3*2)+(2*6)+(1*1)=131
131 % 10 = 1
So 1083162-61-1 is a valid CAS Registry Number.
1083162-61-1Relevant articles and documents
SMALL MOLECULE FERROPTOSIS INDUCERS
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Paragraph 0204; 0207; 0208, (2018/07/29)
The present invention provides, inter alia, a compound according to formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.
