1083168-87-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is used as an intermediate in the synthesis of pyridine compounds that act as modulators of the cystic fibrosis transmembrane conductance regulator (CFTR). These modulators are crucial in the treatment of CFTR-mediated diseases, such as cystic fibrosis, a genetic disorder that affects the respiratory and digestive systems.
In the pharmaceutical industry, this intermediate plays a vital role in the development of new drugs that can help manage or treat diseases associated with the malfunctioning of the CFTR protein. By modulating the activity of CFTR, these pyridine-based compounds can potentially improve the symptoms and quality of life for patients suffering from CFTR-mediated diseases.

Upstream product

• 63071-03-4 2-methoxy-6-methyl-pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 1083169-00-9 4-bromo-2-methoxy-6-methylpyridine 

Downstream Products

• 1309443-98-8 (2-methoxy-6-methylpyridin-4-yl)boronic acid 

Relevant academic research and scientific papers

5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER

Described herein are triazalone compounds of Formula (I) and pharmaceutically acceptable salts thereof. Methods of making and using compounds of Formula (I) are also described. Compounds of Formula (I) and pharmaceutically acceptable salts thereof can be

Cobalt-Catalyzed Regioselective Borylation of Arenes: N-Heterocyclic Silylene as an Electron Donor in the Metal-Mediated Activation of C?H Bonds

C?H Borylation of arenes has been a subject of great interest recently because of its atom-economy and the wide applicability of borylated products in value-added synthesis. A new bis(silylene)cobalt(II) complex bearing a bis(N-heterocyclic silylene)-pyridine pincer ligand (SiNSi) has been synthesized and structurally characterized. It enabled the regioselective catalytic C?H borylation of pyridines, furans, and fluorinated arenes. Notably, it exhibited complementary regioselectivity for the borylation of fluorinated arenes compared to previously known catalytic systems, demonstrating that N-heterocyclic silylene donors have enormous potential in metal-catalyzed catalytic applications.

MORPHOLINOTHIAZOLES AS ALPHA 7 POSITIVE ALLOSTERIC MODULATORS

The present invention relates to morpholinothiazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to positi

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.