1083180-00-0

Basic information

• Product Name: thiazol-4-ylboronic acid pinacol ester
• Synonyms: thiazol-4-ylboronic acid pinacol ester;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole;4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole
• CAS NO: 1083180-00-0
• Molecular Formula: C₉H₁₄BNO₂S
• Molecular Weight: 229.10424
• Mol File: 1083180-00-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 304.72 °C at 760 mmHg
• Flash Point: 138.09 °C
• Appearance: /
• Density: 1.121 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.80±0.10(Predicted)
• CAS DataBase Reference: thiazol-4-ylboronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: thiazol-4-ylboronic acid pinacol ester(1083180-00-0)
• EPA Substance Registry System: thiazol-4-ylboronic acid pinacol ester(1083180-00-0)

Safety Data

• Hazardous Substances Data: 1083180-00-0(Hazardous Substances Data)

Usage

General Description

Thiazol-4-ylboronic acid pinacol ester is an organoboron compound that has a thiazole ring and a boronic acid functional group attached to a pinacol (2,3-dimethyl-2,3-butanediol) ester. It is commonly used in organometallic chemistry as a precursor for the synthesis of various biologically active molecules, pharmaceuticals, and agrochemicals. The boronic acid moiety allows for facile cross-coupling reactions with a variety of electrophiles, making it a valuable building block in organic synthesis. Additionally, the thiazole ring imparts unique chemical and biological properties to the molecule, making it a versatile and important reagent in modern synthetic chemistry.

Upstream product

• 34259-99-9 4-bromo-1,3-thiazole 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities

This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.