1083181-26-3

Basic information

• Product Name: 3-iodo-1H-pyrrolo[3,2-b]pyridine
• Synonyms: 3-iodo-1H-pyrrolo[3,2-b]pyridine;3-Iodo-4-azaindole
• CAS NO: 1083181-26-3
• Molecular Formula: C₇H₅IN₂
• Molecular Weight: 244.03247
• Mol File: 1083181-26-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 360.7±22.0 °C(Predicted)
• Appearance: /
• Density: 2.082
• Storage Temp.: 2-8°C(protect from light)
• PKA: 13.16±0.40(Predicted)
• CAS DataBase Reference: 3-iodo-1H-pyrrolo[3,2-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodo-1H-pyrrolo[3,2-b]pyridine(1083181-26-3)
• EPA Substance Registry System: 3-iodo-1H-pyrrolo[3,2-b]pyridine(1083181-26-3)

Safety Data

• Hazardous Substances Data: 1083181-26-3(Hazardous Substances Data)

Usage

General Description

3-Iodo-1H-pyrrolo[3,2-b]pyridine is a clear, crystalline solid substance that is utilized frequently in chemical research and laboratory experiments. Its systematic name refers to the molecular structure of the compound, which consists of a pyrrole ring fused with a pyridine ring, with an iodine atom attached. The molecular structure of 3-Iodo-1H-pyrrolo[3,2-b]pyridine is important in the field of synthetic organic chemistry, where it is used as a building block to create complex molecules. Its purity, solubility in organic solvents, and properties like melting point/crystal structure can be utilized to study the effect of modifications on the base structure. It has a molar mass of 249.06 g/mol and its CAS number is 143322-57-0.

Upstream product

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 

Downstream Products

• 1204321-20-9 C₁₃H₉FN₂S 
• 1316228-53-1 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[3,2-b]pyridine 
• 1316228-29-1 C₂₁H₂₁N₅O₂ 

Relevant articles and documents

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.

THERAPEUTIC INHIBITORY COMPOUNDS

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

4-AZAINDOLE DERIVATIVES

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