108321-53-5

Basic information

• Product Name: URIDINE 5'-TRIPHOSPHATE TRIS SALT
• Synonyms: URIDINE 5'-TRIPHOSPHATE TRIS SALT;UTP TRIS SALT;uridine 5'-triphosphate tris type vi;Uridine 5'-triphosphate (UTP)
• CAS NO: 108321-53-5
• Molecular Formula: C13H26N3O18P3
• Molecular Weight: 605.28
• Mol File: 108321-53-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• Solubility: H2O: soluble50mg/mL, clear, colorless
• CAS DataBase Reference: URIDINE 5'-TRIPHOSPHATE TRIS SALT(CAS DataBase Reference)
• NIST Chemistry Reference: URIDINE 5'-TRIPHOSPHATE TRIS SALT(108321-53-5)
• EPA Substance Registry System: URIDINE 5'-TRIPHOSPHATE TRIS SALT(108321-53-5)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 22-26-36-45
• WGK Germany: 3
• Hazardous Substances Data: 108321-53-5(Hazardous Substances Data)

Usage

Description

Uridine 5'-triphosphate tris salt, also known as UTP tris salt, is a polyphosphate analogue of the nucleoside uridine. It plays a crucial role in various biological processes, including signal transduction and energy transfer.

Uses

Used in Pharmaceutical Industry:
Uridine 5'-triphosphate tris salt is used as a precursor in the synthesis of potent and selective agonists at the G-protein-coupled P2Y receptors. These agonists have potential applications in the treatment of various diseases and disorders.
Used in Research and Development:
Uridine 5'-triphosphate tris salt is used as a component of non-radioactive nucleoside triphosphate solutions in in vitro RNA polymerase assays. This allows researchers to study the activity and regulation of RNA polymerases, which are essential for gene expression.
Used in Cell Biology:
Uridine 5'-triphosphate tris salt is used as a P2Y2 agonist in human embryonic kidney cells (HEK293T) to investigate its activation potential on the purinergic P2Y2 receptor. This helps researchers understand the role of P2Y2 receptors in cellular signaling and their potential as therapeutic targets.
Used in Drug Discovery:
Uridine 5'-triphosphate tris salt is used in dynamic mass redistribution (DMR) assays to study the interactions between molecules and their targets. This information can be valuable for the development of new drugs and therapeutic agents.

Biochem/physiol Actions

Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic?(P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway.