1083282-02-3Relevant articles and documents
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00628; 00630-00631, (2021/08/13)
The present invention provides compounds, compositions thereof, and methods of using the same.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00920; 003338; 003341-003342, (2021/01/23)
The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
A Imidazolepyrimidine carboxylic acid compound and method for preparing the same
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Paragraph 0020; 0021; 0023; 0025, (2018/01/19)
The invention relates to an imidazolopyrimidine carboxylic acid type compound and a preparation method thereof. The compound is 8-carboxylic acid-imidazo[1,5-a]pyrimidine. The preparation method comprises the steps of (1) reacting a compound 1 namely imidazoleamide with 1,3-malondialdehyde in an autoclave for performing closed ring reaction at a temperature of 100 DEG C to form a compound 2 with an imidazolopyrimidine structure; (2) converting amide in the compound 2 into acid under a condition of concentrated hydrochloric acid to obtain a compound 3. The obtained final product has an extensive use prospect in resisting tristimania.