1083282-61-4

Upstream product

• 955961-34-9 3-chloro-2-oxo-3-m-tolylpropionic acid methylester 
• 620-23-5 m-tolyl aldehyde 
• 1083282-58-9 2-cyclopropyl-5-(3-methyl-phenyl)-thiazole-4-carboxylic acid methyl ester 

Downstream Products

• 1193495-61-2 (R)-(2-cyclopropyl-5-m-tolyl-thiazol-4-yl)-[3-(4-trifluoromethyl-pyrimidin-2-ylamino)-piperidin-1-yl]-methanone 
• 1193496-85-3 (R)-[1-(2-cyclopropyl-5-m-tolyl-thiazole-4-carbonyl)-piperidin-3-yl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

PIPERIDINE AND PYROOLIDINE COMPOUNDS

The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

2-CYCLOPROPYL-THIAZOLE DERIVATIVES

The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as med

PIPERIDINE AND PYRROLIDINE COMPOUNDS

The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as m

2-CYCLOPROPYL-THIAZOLE DERIVATIVES

The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.