1083357-66-7Relevant articles and documents
Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi
Van Well, Renate M.,Collet, Beatrice Y. M.,Field, Robert A.
, p. 2175 - 2177 (2008)
A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase. Georg Thieme Verlag Stuttgart.
