108338-19-8

Basic information

• Product Name: 4-Nitropicolinaldehyde
• Synonyms: 4-Nitropicolinaldehyde;4-Nitro-2-pyridinecarbaldehyde;4-Nitro-2-pyridinecarboxaldehyde
• CAS NO: 108338-19-8
• Molecular Formula: C₆H₄N₂O₃
• Molecular Weight: 152.109
• Mol File: 108338-19-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 275.3±25.0℃ (760 Torr)
• Flash Point: 120.3±23.2℃
• Appearance: /
• Density: 1.432±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.00515mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.21±0.10(Predicted)
• CAS DataBase Reference: 4-Nitropicolinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitropicolinaldehyde(108338-19-8)
• EPA Substance Registry System: 4-Nitropicolinaldehyde(108338-19-8)

Safety Data

• Hazardous Substances Data: 108338-19-8(Hazardous Substances Data)

Usage

General Description

4-Nitropicolinaldehyde, also known as 4-Nitro-2-pyridinecarbaldehyde or 2-pyridinecarboxaldehyde, 4-nitro, is a chemical compound primarily utilized in scientific and industrial applications. Its formula is C6H4N2O3 and its molecular weight is 152.108 g/mol. This beige solid chemical substance has a melting point of approximately 187-189 degrees Celsius. It's highly soluble in polar solvents and can be created through various methods, such as dehydration. Safety precautions must be taken while handling 4-Nitropicolinaldehyde due to its potentially harmful effects on the eyes, skin, and respiratory system.

InChI:InChI=1/C6H4N2O3/c9-4-5-3-6(8(10)11)1-2-7-5/h1-4H

Upstream product

• 98197-88-7 4-nitro-2-(hydroxymethyl)pyridine 
• 109-06-8 α-picoline 
• 131747-32-5 2-acetoxymethyl-4-nitropyridine 
• 931-19-1 2-methylpyridine N-oxide 
• 131747-33-6 2-acetoxymethyl-4-nitropyridine 
• 5470-66-6 2-methyl-4-nitropyridine N-oxide 
• 36625-64-6 2-hydroxymethyl-4-nitropyridine 

Downstream Products

• 131747-63-2 4-bromo-2-pyridinecarboxaldehyde 
• 108337-77-5 2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate 

Relevant articles and documents

Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase

Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that incorporate a 7-indolizinylamino or 2-naphthylamino substituent on a pyrimidine or 1,3,5-triazine core. The most potent compounds show below 10 nanomolar activity towards wild-type HIV-1 and variants bearing Tyr181Cys and Lys103Asn/Tyr181Cys resistance mutations. The compounds also feature good aqueous solubility. Crystal structures for two complexes enhance the analysis of the structure-activity data.

A convenient synthetic route to a useful synthon: 4-bromo-2-pyridinecarboxaldehyde

We have developed a novel four-step method to synthesise 4-bromo-2-pyridinecarboxaldehyde, from 2-picoline-N-oxide via 4-nitro-2-pyridinecarboxaldehyde, under mild reaction conditions.

PHTHALAZINONE DERIVATIVES

A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; D is selected from: (i) ?where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected f