108338-20-1

Basic information

• Product Name: 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE
• Synonyms: 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE;2-(Trifluoromethyl)-4-pyridinecarboxaldehyde;2-Trifluoromethyl-pyridine-4-carbaldehyde;4-Pyridinecarboxaldehyde, 2-(trifluoromethyl)-;2-(trifluoroMethyl)isonicotinaldehyde;2-(Trifluoromethyl)pyridine-4-carboxaldehyde, 4-Formyl-2-(trifluoromethyl)pyridine;4-ForMyl-2-(trifluoroMethyl)pyridine;2-(Trifluoromwthyl)pyridine-4-carbaldehyde
• CAS NO: 108338-20-1
• Molecular Formula: C7H4F3NO
• Molecular Weight: 175.11
• Mol File: 108338-20-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 188.4 °C at 760 mmHg
• Flash Point: 67.7 °C
• Appearance: /
• Density: 1.369 g/cm³
• Vapor Pressure: 0.601mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.42±0.20(Predicted)
• CAS DataBase Reference: 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE(108338-20-1)
• EPA Substance Registry System: 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE(108338-20-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 108338-20-1(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethyl)-pyridine-4-carboxaldehyde is a chemical compound with the molecular formula C7H4F3NO. It is a yellow liquid with a fruity odor, and it is used as a building block in organic synthesis. The trifluoromethyl group makes this compound useful in medicinal chemistry and agrochemical applications. It is also used as a reagent in the synthesis of pharmaceuticals and other fine chemicals. 2-(TRIFLUOROMETHYL)-PYRIDINE-4-CARBOXALDEHYDE has potential as a versatile intermediate for the development of new materials and drugs due to its unique chemical properties.

InChI:InChI=1/C7H4F3NO/c8-7(9,10)6-3-5(4-12)1-2-11-6/h1-4H

Upstream product

• 131747-41-6 2-(trifluoromethyl)-4-pyridinecarboxylic acid 
• 131748-14-6 4-chloro-2-trifluoromethylpyridine 
• 131747-61-0 <2-(trifluoromethyl)pyridin-4-yl>methanol 

Downstream Products

• 108338-12-1 2,6-Dimethyl-4-(2-trifluoromethyl-4-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 

Relevant articles and documents

Microwave synthesis method of 6-trifluoromethylpyridylaldehyde

The invention relates to a microwave synthesis method of 6-trifluoromethylpyridylaldehyde. According to the method, a reaction is performed in a reaction tank by using a microwave irradiation technique; 1 eq of 6-trifluoromethylpyridinemethanol is added, a solvent is added to dissolve 6-trifluoromethylpyridinemethanol, 0.01-0.1 eq of a catalyst and 1-1.5 eq of an oxidant are added, microwave powerand temperature are set to react after feeding is finished, after the reaction is finished, rotary evaporation and concentration is performed on the reaction solution to obtain a solid product, and finally the solid product is separated and purified to obtain the 6-trifluoromethylpyridylaldehyde. Compared with the prior art, the method provided by the invention has the advantages of short reaction time, mild conditions, few side reactions and high yield, simplifies the production process, reduces the production cost and cycle, is easy to realize the popularization of industrial production, and is especially suitable for large-scale production of an intermediate 6-trifluoromethyl nicotinaldehyde of a colony stimulating factor 1 receptor (CSF-1R) inhibitor.

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