1083414-79-2Relevant academic research and scientific papers
Desymmetrisation of biphenyl-based carbohydrate receptors: A nonbonding pillar in one corner of the cage
Challinor, Lee,Klein, Emmanuel,Davis, Anthony P.
, p. 2137 - 2141 (2008)
We report a new addition to the family of biphenyl-based carbohydrate receptors, derived by replacing one out of four isophthalamide (diamide) linkages with the corresponding diester. The alteration results in lower binding constants, perhaps reflecting the entropic penalty for lowering receptor symmetry. However, the synthesis allows access to many related host molecules, with potential for restoring and raising affinities and tuning selectivities. Georg Thieme Verlag Stuttgart.
