108342-84-3Relevant articles and documents
Chemistry of Nitrosamines, V.-Syntheses of α-Functional N-Nitrosodialkylamines: Thioethers and Dithiocarbamates
Rugewitz-Blackholm, Beate,Wiessler, Manfred
, p. 583 - 588 (2007/10/02)
The in vivo reaction products of electrophilic compounds with glutathione are excreted as S-alkyl-N-acetylcysteins (mercapturates) after enzymatic degradation.The results clearly show that mercapturates as 1-substituted N-nitrosodialkylamines 11 are chemically stable enough to be isolated and characterized.The reactions of 1-chloro-N-nitrosodialkylamines 5 with 3,4-dichlorothiophenol, ethanethiol, and N,N-diethyldithiocarbamate illustrate the high tendency of formation of 1-thiosubstituted nitrosamines.