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Mannich reaction: an approach for the synthesis of water soluble Mulundocandin (cas 108351-20-8) analogues☆☆☆09/06/2019

Semisynthetic modifications at Hydroxy tyrosine (Htyr) unit of mulundocandin (1) were carried out to improve its aqueous solubility. A single step introduction of substituted aminomethyl groups at the ortho position(s) of phenolic hydroxyl of HTyr unit of mulundocandin has been achieved in 7–85...detailed

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