108366-80-9

Upstream product

• 7580-85-0 tert-butyl glycidyl ether 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 158937-14-5 1-carbomethoxy-4'-<<4-<<(tert-butyloxy)ethyl>oxy>phenyl>ethynyl>biphenyl 
• 1444301-53-4 (3aS,4R,6S,6aR)-N-benzyl-6-((2-tert-butoxy)ethoxy)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-amine 
• 1451195-46-2 tert-butyl (3-((3aS,4R,6S,6aR)-6-(2-(tert-butoxy)ethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate 
• 1444301-58-9 (3aS,4R,6S,6aR)-6-(2-(tert-butoxy)ethoxy)-2,2-dimethyl-N-trityl-tetrahydro-3ah-cyclopenta[d][1,3]dioxol-4-amine 

Relevant academic research and scientific papers

Glucopyranosyl derivative and application thereof in medicines

The invention relates to a glucopyranosyl derivative used as a sodium-dependent glucose transporter (SGLT) inhibitor, a medicinal composition containing the derivative, and an application of the derivative and the medicinal composition in medicines, and especially relates to the glucopyranosyl derivative represented by formula (I) or a pharmaceutically acceptable salt or all stereoisomers thereof, or the medicinal composition containing the derivative, and a use of the derivative and the medicinal composition in the preparation of medicines for treating diabetes and diabetes related diseases.

MUSCARINIC AGONISTS

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

Molecular Desidn of Crown Ethers. 4. Syntheses and Selective Cation Binding of 16-Crown-5 and 19-Crown-6 Lariats

A number of new lariat 16-crown-5 and 19-crown-6 ethers posesing a variety of single or double side arm(s) were synthesized, and their cation-binding abilities were evaluated by solvent extraction technique.In general, the extractabilities of the 16-crown-5 lariats for most mono- and divalent cations increased gradually with extending oxyethylene side arm.However, sodium and silver ions, which are best size fitted to the crown cavity, showed peac extractability/selectivity at a specific length of the donating side arm.The complexation stoichiometry is 1 : 1 forall cations employed as confirmed by measurement of the extraction equilibrium constants for the single-armed 16-crown-5 (3p).The tetrasubstituted pivot carbon is shown to be a reguirement for lariat 16-crown-5 to effect extra side-arm ligation, although the second side arm of lariat ether 3e seems ineffective in extractability enhancement with reference to the single-armed analogue 3p.By contrast, the corresponding 19-crown-5 lariat with potential donor side arms at an appropiate position did not show any enhancement in extractability for most cations, which may be attributed to its flexible framework.