108383-95-5

Basic information

• Product Name: naltiazem
• Synonyms: naltiazem
• CAS NO: 108383-95-5
• Molecular Formula: C26H28N2O4S
• Molecular Weight: 464.57652
• Mol File: 108383-95-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 663.9°C at 760 mmHg
• Flash Point: 355.3°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 1.71E-17mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: naltiazem(CAS DataBase Reference)
• NIST Chemistry Reference: naltiazem(108383-95-5)
• EPA Substance Registry System: naltiazem(108383-95-5)

Safety Data

• Hazardous Substances Data: 108383-95-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C26H28N2O4S/c1-17(29)32-23-24(19-9-12-20(31-4)13-10-19)33-25-21-8-6-5-7-18(21)11-14-22(25)28(26(23)30)16-15-27(2)3/h5-14,23-24H,15-16H2,1-4H3/t23-,24+/m1/s1

Upstream product

• 108383-88-6 (+)-cis-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-naphtho<1,2-b><1,4>thiazepin-4(5H)-one hydrochloride 

Relevant articles and documents

Glycidic acid ester and process of preparation

A process for the preparing a compound of the formula STR1 wherein R 1 and R 2 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl or nitro; or R 1 and R 2 taken together with the benzene ring to which they are attached are naphthalene, and Ar is p-lower alkoxy phenyl.which comprises reacting STR2 wherein R 1 and R 2 are as described above with the compound of the formula STR3 wherein Ar is as described above, in an aromatic organic compound. The intermediates formed by the process of the invention are useful in the production of thiazepin-4(5H)-ones which have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure and agents for treating ischemia.