108394-74-7Relevant academic research and scientific papers
Stereochemical Studies of Polyols from the Polyene Macrolide Lienomycin
Pawlak, Jan,Nakanishi, Koji,Iwashita, Takashi,Borowski, Edward
, p. 2896 - 2901 (1987)
Because the polyene macrolides are characterized by noncrystallinity and the presence of numerous chiral hydroxyl groups, elucidation of their stereochemistry has constantly been a challenging problem; to date the full stereochemistry of only amphotericin B is known.Taking lienomycin as an example, we have devised methods to determine the relative and absolute configurations of acyclic polyols.This has resulted in clarifying 10 of the 15 chiral centers in the aglycone.
