108395-12-6

Basic information

• Product Name: DL-GLUTAMIC-2-13C ACID
• Synonyms: DL-GLUTAMIC-2-13C ACID;DL-GLUTAMIC-2-13C ACID, 99 ATOM % 13C;dl-glutamic acid-2-13c
• CAS NO: 108395-12-6
• Molecular Formula: C5H9NO4
• Molecular Weight: 148.14
• Product Categories: Alphabetical Listings;G-H;Stable Isotopes
• Mol File: 108395-12-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 185 °C (dec.)(lit.)
• Appearance: /
• CAS DataBase Reference: DL-GLUTAMIC-2-13C ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DL-GLUTAMIC-2-13C ACID(108395-12-6)
• EPA Substance Registry System: DL-GLUTAMIC-2-13C ACID(108395-12-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 108395-12-6(Hazardous Substances Data)

Upstream product

• 1259016-65-3 (2S)-[2,3,4,5,6-⁽¹³⁾C₅;1-⁽¹⁵⁾N]N-tert-butoxycarbonyl-5-(tert-butyldimethylsilyloxymethyl)-1H-pyrrol-2(5H)-one 
• 554428-67-0 (2S,3S,4R)-[3,4-⁽²⁾H₂;2,3,4,5,6-⁽¹³⁾C₅;1-⁽¹⁵⁾N]N-tert-butoxycarbonyl-5-(tert-butyldimethylsilyloxymethyl)pyrrolidin-2-one 
• 1259016-71-1 C₅⁽¹³⁾C₅H₁₃⁽²⁾H₂⁽¹⁵⁾NO₅ 
• 1136765-17-7 C₁₂⁽¹³⁾CH₂₁⁽²⁾HN₂O₆ 
• 1136765-26-8 C₁₂⁽¹³⁾CH₂₀⁽²⁾H₂N₂O₆ 
• 59681-32-2 ¹³C₅-¹⁵N₂-L-glutamine 
• 131157-42-1 <3-13C>-L-alanine 

Downstream Products

• 1220967-81-6 C₇⁽¹³⁾C₅H₁₄N₂O₅ 
• 1220967-83-8 C₉⁽¹³⁾C₅H₁₆N₂O₆ 
• 123953-28-6 1,2-⁽¹³⁾C₂-α-ketoglutaric acid 
• 554429-02-6 SAIL proline 
• 554428-63-6 (2S,3S,4R)-[1,2,3,4,5-13C5;2,5-13N2;3,4-2H2]glutamine 

Relevant articles and documents

Specific detection of cellular glutamine hydrolysis in live cells using HNCO triple resonance NMR

Glutamine plays key roles as a biosynthetic precursor or an energy source in cancers, and interest in its metabolism is rapidly growing. However, the proper evaluation of glutamine hydrolysis, the very first reaction in the entire glutaminolysis, has been difficult. Here, we report a triple resonance NMR-based assay for specific detection of glutaminase activity carrying out this reaction using stable-isotope labeled glutamine. Compared to conventional methods involving coupled enzyme assays, the proposed approach is direct because it detects the presence of the H-N-CO amide spin system. In addition, the method is unique in enabling the measurement of glutamine hydrolysis reaction in real-time in live cells. The approach was applied to investigating the effects of a glutaminase inhibitor and the inhibitory effects of glucose on glutamine metabolism in live cells. It can be easily applied to studying other signals that affect cellular glutamine metabolism.

LYSINE ISOTOPOLOGUES, COMPOSITIONS COMPRISING THE SAME AND METHODS OF SYNTHESIS

This invention relates to lysine isotopologues of Formulas I and 1-A, as described herein, and processes for synthesizing the same and derivatives and intermediates involved therein. In one aspect, described herein is a chemical compound comprising an isotopically labeled analog, i.e., an isotopologue of a standard or naturally occurring lysine. The lysine isotopologue is synthetically formed to have stable isotopes of elements incorporated at selected positions. As such, the lysine isotopologue has a molecular mass different from the mass of a standard or naturally occurring lysine.

Assymetric synthesis of (2S,3R)- and (2S,3S)-[2-13C;3-2H] glutamic acid

We have developed a synthetic route for (2S,3R)- and (2S,3S)-[2-13C;3-2H] glutamic acids with high enantioselectivity. The key reactions in this synthesis are the asymmetric reduction of the 2,3-didehydroornithine derivative using th