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108395-15-9

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108395-15-9 Usage

Uses

(2-Ketoglutaric Acid-13C1) Labelled 2-Ketoglutaric Acid is used in enzymic preparation and conversion to radiolabeled isocitric acid

Check Digit Verification of cas no

The CAS Registry Mumber 108395-15-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,3,9 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 108395-15:
(8*1)+(7*0)+(6*8)+(5*3)+(4*9)+(3*5)+(2*1)+(1*5)=129
129 % 10 = 9
So 108395-15-9 is a valid CAS Registry Number.

108395-15-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Ketoglutaric Acid-13C1

1.2 Other means of identification

Product number -
Other names 2-oxopentanedioic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108395-15-9 SDS

108395-15-9Upstream product

108395-15-9Downstream Products

108395-15-9Relevant articles and documents

ISOTOPES OF ALPHA KETOGLUTARATE AND RELATED COMPOUNDS AND THEIR USE IN HYPERPOLARIZED IMAGING

-

Paragraph 0172-0175, (2021/07/24)

A compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Ca, Cb, Cd, and n are the same as described in the specification. Disclosed is a method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is the compound of Formula I, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient; and diagnosing or monitoring the patient by hyperpolarized 13C-MRI. Also disclosed is a method of synthesizing 1-13C- 5-12C-diacid.

TCA cycle involved enzymes SucA and Kgd, as well as MenD: Efficient biocatalysts for asymmetric C-C bond formation

Beigi, Maryam,Waltzer, Simon,Fries, Alexander,Eggeling, Lothar,Sprenger, Georg A.,Müller, Michael

supporting information, p. 452 - 455 (2013/04/10)

Asymmetric mixed carboligation reactions of α-ketoglutarate with different aldehydes were explored with the thiamine diphosphate dependent enzymes SucA from E. coli, Kgd from Mycobacterium tuberculosis, and MenD from E. coli. All three enzymes proved to be efficient biocatalysts to selectively deliver chiral δ-hydroxy-γ-keto acids with moderate to excellent stereoselectivity. The high regioselectivity is due to the preserved role of α-ketoglutarate as acyl donor for these enzyme-catalyzed reactions.

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