108418-77-5Relevant academic research and scientific papers
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
Dwyer, Michael P.,Paruch, Kamil,Alvarez, Carmen,Doll, Ronald J.,Keertikar, Kerry,Duca, Jose,Fischmann, Thierry O.,Hruza, Alan,Madison, Vincent,Lees, Emma,Parry, David,Seghezzi, Wolfgang,Sgambellone, Nicole,Shanahan, Frances,Wiswell, Derek,Guzi, Timothy J.
, p. 6216 - 6219 (2008/03/18)
A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the in-vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors.
Novel imidazopyrazines as cyclin dependent kinase inhibitors
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Page/Page column 16, (2008/06/13)
In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, me
