108419-03-0Relevant articles and documents
Palladium-catalyzed addition of arylboronic acids to aldehydes
Yamamoto, Tetsuya,Ohta, Tetsuo,Ito, Yoshihiko
, p. 4153 - 4155 (2005)
(Chemical Equation Presented) Arylboronic acids react with aldehydes in the presence of a base and a catalytic amount of a palladium(0) complex with chloroform, affording the corresponding secondary alcohols in good yields. General palladium complexes have no catalytic activity without chloroform. Chloroform is essential for this reaction, and palladium complex that was prepared from Pd(PPh3)4 with CHCl3 showed good catalytic acitivty as well.
The dimerization of radical anions of aromatic carboxylic acids competing with the self-protonation reaction
Rubinskaya, T. Ya.,Mendkovich, A. S.,Lisitsina, N. K.,Yakovlev, I. P.,Gultyai, V. P.
, p. 1658 - 1661 (1993)
Quantum-chemical calculations (CNDO/2) of the theoretical relationship between the rate constants for the dimerization and self-protonation of radical anions show that dimer formation in the one-electron electroreduction of aromatic carboxylic acids (benzoic (1), 1-naphthoic (2), and 9-anthroic (3)) is most probable for 1.It is established that during the constant potential electrolysis (CPE) of 1 a mixture of "head-to-tail" dimers is formed in the presence of 0.1 M Bu4NClO4 (DMF).Their ratio depends on the amount of electricity passed through the solution.The CPE of 2 in the presence of 20 percent H2O affords 1,4-dihydro-1-naphthoic acid in up to 70 percent yield.The high yield ( ca. 70 percent) of 9,10-dihydro-9-anthroic acid during the CPE of 3 can be accounted for the decomposition of the dimeric product followed by protonation of the anionic species. - Key words: dimerization, self-protonation, aromatic carboxylic acids, electroreduction, radical anions.
Halogen-Zinc Exchange Reaction of Haloaromatics with Lithium Trimethylzincate
Kondo, Yoshinori,Takazawa, Nobuo,Yamazaki, Chizuru,Sakamoto, Takao
, p. 4717 - 4718 (1994)
Lithium aryldimethylzincates were prepared using a halogen-zinc exchange reaction of aromatic halides with lithium trialkylzincates, and the reactions with some electrophiles for the functionalization of aromatic rings were investigated.
Electroreductive coupling of organic halides with aldehydes catalyzed by nickel(0) complex with 2,2′-bipyridine
Budnikova,Keshner,Kargin
, p. 453 - 456 (2001)
A method of electrosynthesis of secondary alcohols from aldehydes and organic halides under the action of nickel(0) complexes is proposed. The key stage is addition of σ-complex RNi(I)bipy (bipy is 2,2′-bipyridine) to the aldehyde group.
Light-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions
Cao, Dawei,Xia, Shumei,Pan, Pan,Zeng, Huiying,Li, Chao-Jun,Peng, Yong
supporting information, p. 7539 - 7543 (2021/10/12)
Alcohols are versatile structural motifs of pharmaceuticals, agrochemicals and fine chemicals. With respect to green chemistry, the development of more sustainable and cost-efficient processes for converting ketones/aldehydes to alcohols is highly desired. Herein, a direct light-driven strategy for reducing ketones/aldehydes to alcohols using isopropanol as the reducing agent and solvent, in the presence of t-BuOLi, under an air atmosphere at room temperature is developed. This operationally simple light-promoted Meerwein-Ponndorf-Verley (MPV) type reduction can be used to produce various benzylic alcohol derivatives as well as applied to bioactive molecules and PEEK model compounds, demonstrating its application potential.
INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR
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Page/Page column 119, (2021/10/11)
Chromanone compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the inhibition of antigen presentation by HLA-DR.
