108444-20-8

Basic information

• Product Name: 3-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• Synonyms: 3-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 108444-20-8
• Molecular Weight: 255.273
• Mol File: 108444-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(108444-20-8)
• EPA Substance Registry System: 3-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(108444-20-8)

Safety Data

• Hazardous Substances Data: 108444-20-8(Hazardous Substances Data)

Upstream product

• 6833-21-2 2-methoxy-N-phenylbenzamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 147637-22-7 7-Methoxy-1-(2-methoxy-phenyl)-1,3-dihydro-isobenzofuran-1-ol 
• 108444-17-3 (4-Methoxy-3-oxo-2-phenyl-2,3-dihydro-1H-isoindol-1-yl)-acetic acid ethyl ester 
• 147637-17-0 2-hydroxymethyl-6-methoxybenzanilide 
• 28281-58-5 7-methoxyisobenzofuran-1(3H)-one 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 23: Synthetic strategies based on ortho-aromatic metallation. Synthesis of 4b- arylisoindolo[2,1-a]quinoline derivatives

The synthesis of the 2-aryl-3-hydroxyisoindol-1-ones 3 and their successive conversion via the reaction with 1-methoxy-1- trimethylsilyloxyethene in the presence of titanium(IV) chloride into 3- carboxymethylphthalimides 7 and subsequent cyclization via sequential treatment with oxalyl chloride and aluminium chloride as a way of regiospecific transformation of the benzenecarbocylic acids into the corresponding isoindolo[2,1-a]quinoline-5, 11-diones 5 is described. (C) 2000 Elsevier Science Ltd.

A Novel Synthesis of N-Substituted-3-carboethoxymethylphthalimidines

A novel synthesis of N-substituted-3-carboethoxymethylphthalimidines 5 is described from secondary benzamides.The benzamides 1 on lithiation with n-butyllithium followed by treatment with dimethylformamide furnish 3-hydroxyphthalimidines 2 in 74-84percent