108446-67-9

Upstream product

• 108446-85-1 2-[3-(4-Chloro-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester 
• 141-82-2 malonic acid 
• 36663-00-0 1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde 
• 57845-08-6 p-chloroacetophenone phenylhydrazone 

Downstream Products

• 108446-79-3 β-[3-(p-Chlorophenyl)-1-phenylpyrazol-4-yl]propionic acid 
• 55432-14-9 3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid 

Relevant academic research and scientific papers

Efficient ecofriendly synthesis of pyrazole acryloyl analogs by amino acid catalysis

An easy and effective green approach of Knoevenagel condensation and arylidene formation with the substrates involves pyrazole-3-carbaldehydes and active methylenes under catalytic action of glycine (the simplest amino acid) in dimethylsulfoxide. These re

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.