108446-80-6

Usage

Family

Pyrazole derivatives

Chemical structure

contains a pyrazole ring with a bromophenyl and phenyl group attached to it

Properties

potential pharmaceutical and medicinal properties, exhibits anti-inflammatory and analgesic activities

Potential uses

being studied for treatment of pain and inflammatory conditions
Promising candidate for further research and development in drug discovery and medicinal chemistry

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 36640-41-2 3-(4-bromophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 10591-75-0 4-bromoacetophenone phenylhydrazone 
• 108446-86-2 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester 
• 108446-68-0 2-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid 
• 108446-73-7 (E)-3-[3-(4-Bromo-phenyl)-1-phenyl-1H-pyrazol-4-yl]-acrylic acid 

Relevant academic research and scientific papers

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl and 1,3-diarylpyrazol-4-yl propanoic acids

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl (4a-h) and 1,3-diarylpyrazol-4-yl propanoic acids (5a-h) using Meldrum's acid (1) from the corresponding carboxaldehydes (2 & 3) is reported herein.

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.