108463-29-2Relevant academic research and scientific papers
Reactions with α-Substituted Cinnamonitriles. A Novel Synthesis of Hexa-substituted Pyridines
Hammouda, Hamdy A.,El-Reedy, Ahmed M.,Hussain, Sohair M.
, p. 1203 - 1206 (2007/10/02)
Whereas acetoacetanilide (II) reacted with α-cyano- and α-benzoylcinnamonitrile derivatives Ia-e to give hexa-substituted pyridines III and V, it reacted with α-carboxamido- and α-thiocarboxamidocinnamonitrile derivatives If-h to afford penta-substituted pyridines VI.One mole of acetonedicarboxylic acid dianilide (VII) reacted with two moles of each of α-cyano- and α-thiocarboxamidocinnamonitriles Ia, b, f,g to yield the dipyridyl ketones VIII and IX, respectively.On the other hand, α-benzoyl- and α-ethoxycarbonylcinnamonitriles Ic, d, i, j reacted with VII in equimolecular ratio to give the pyran derivatives X and XI, respectively.Several schemes were proposed to illustrate reactions steps.The structures of the synthesized compounds were proved by chemical and spectral methods.
