1084734-42-8

Basic information

• Product Name: (R)-ethyl N-acetylaziridine-carboxylate
• CAS NO: 1084734-42-8
• Molecular Weight: 157.169
• Mol File: 1084734-42-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-ethyl N-acetylaziridine-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl N-acetylaziridine-carboxylate(1084734-42-8)
• EPA Substance Registry System: (R)-ethyl N-acetylaziridine-carboxylate(1084734-42-8)

Safety Data

• Hazardous Substances Data: 1084734-42-8(Hazardous Substances Data)

Upstream product

• 86852-11-1 diethoxyltriphenylphosphorane 
• 108-24-7 acetic anhydride 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 
• 2104-89-4 D-serine methyl ester 

Relevant articles and documents

The structure?activity relationship of the 3-Oxy site in the anticonvulsant (R)- N -benzyl 2-acetamido-3-methoxypropionamide

Lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-1) is a low molecular weight anticonvulsant recently introduced in the United States and Europe for adjuvant treatment of partial-onset seizures in adults. In this study, we define the structure?activity relationship (SAR) for the compound's 3-oxy site. Placement of small nonpolar, nonbulky substituents at the 3-oxy site provided compounds with pronounced seizure protection in the maximal electroshock (MES) seizure test with activities similar to (R)-1. The anticonvulsant activity loss that accompanied introduction of larger moieties at the 3-oxy site in (R)-1 was offset, in part, by including unsaturated groups at this position. Our findings were similar to a recently reported SAR study of the 4?-benzylamide site in (R)-1 (J. Med. Chem. 2010, 53, 1288 ?1305). Together, these results indicate that both the 3-oxy and 4?-benzylamide positions in (R)-1 can accommodate nonbulky, hydrophobic groups and still retain pronounced anticonvulsant activities in rodents in the MES seizure model.