108481-92-1

Basic information

• Product Name: 2-Amino-4-(4-isopropylphenyl)- thiazole
• Synonyms: 2-Amino-4-(4-isopropylphenyl)- thiazole;4-[4-(1-METHYLETHYL)PHENYL)-2-THIAZOLAMINE;4-(4-propan-2-ylphenyl)-1,3-thiazol-2-amine;4-(4-isopropylphenyl)-1,3-thiazol-2-amine(SALTDATA: FREE);4-(4-isopropylphenyl)-2-thiazolamine;4-(4-isopropylphenyl)thiazol-2-amine
• CAS NO: 108481-92-1
• Molecular Formula: C₁₂H₁₄N₂S
• Molecular Weight: 218.31796
• Mol File: 108481-92-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 374 °C at 760 mmHg
• Flash Point: 180 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 8.63E-06mmHg at 25°C
• Refractive Index: 1.609
• PKA: 4.46±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4-(4-isopropylphenyl)- thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-(4-isopropylphenyl)- thiazole(108481-92-1)
• EPA Substance Registry System: 2-Amino-4-(4-isopropylphenyl)- thiazole(108481-92-1)

Safety Data

• Hazardous Substances Data: 108481-92-1(Hazardous Substances Data)

Usage

General Description

2-Amino-4-(4-isopropylphenyl)- thiazole, also known as aminoisobutyryl-thiazole, is a chemical compound with the molecular formula C12H14N2S. It is a thiazole derivative with a substituted amino group and an isopropylphenyl group. 2-Amino-4-(4-isopropylphenyl)- thiazole is primarily used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block for the creation of other organic compounds. 2-Amino-4-(4-isopropylphenyl)- thiazole has a variety of potential applications in the pharmaceutical industry, including in the development of new drugs for the treatment of various medical conditions. Its properties and structure make it a valuable compound for further research and development.

InChI:InChI=1/C12H14N2S/c1-8(2)9-3-5-10(6-4-9)11-7-15-12(13)14-11/h3-8H,1-2H3,(H2,13,14)

Upstream product

• 51012-62-5 α-bromomethyl 4-isopropylphenyl ketone 
• 17356-08-0 thiourea 
• 645-13-6 4-isopropylacetophenone 
• 2103-94-8 4-(4-bromophenyl)-1,3-thiazol-2-amine 

Downstream Products

• 1400283-75-1 C₂₅H₂₉N₃O₃S₂ 
• 109943-23-9 sulfanilic acid-[4-(4-isopropyl-phenyl)-thiazol-2-ylamide] 
• 112657-58-6 N-acetyl-sulfanilic acid-[4-(4-isopropyl-phenyl)-thiazol-2-ylamide] 

Relevant articles and documents

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Stereoretentive Pd-catalysed Stille cross-coupling reactions of secondary alkyl azastannatranes and aryl halides

The development of transition metal-catalysed cross-coupling reactions has greatly influenced the manner in which the synthesis of complex organic molecules is approached. A wide variety of methods are now available for the formation of C(sp2)-C(sp2) bonds, and more recent work has focused on the use of C(sp3) electrophiles and nucleophiles. The use of secondary and tertiary alkyl nucleophiles in cross-coupling reactions remains a challenge because of the propensity of these alkyl groups to isomerize under the reaction conditions. Here, we report the development of a general Pd-catalysed process for the stereoretentive cross-coupling of secondary alkyl azastannatrane nucleophiles with aryl chlorides, bromides, iodides and triflates. Coupling partners with a wide range of electronic characteristics are well tolerated. The reaction occurs with minimal isomerization of the secondary alkyltin nucleophile, and with retention of absolute configuration. This process constitutes the first general method to use secondary alkyltin reagents in cross-coupling reactions.

SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS

The present invention provides substituted thiazole and pyrimidine derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.