108481-92-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-4-(4-isopropylphenyl)-thiazole is used as a key intermediate for the synthesis of various pharmaceuticals, leveraging its unique structure to contribute to the development of new drugs for treating a range of medical conditions. Its properties make it a valuable compound for ongoing research and development in drug discovery.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-4-(4-isopropylphenyl)-thiazole serves as an intermediate in the production of agrochemicals, potentially enhancing crop protection and management through its incorporation into effective and targeted compounds.
Used as a Building Block in Organic Chemistry:
2-Amino-4-(4-isopropylphenyl)-thiazole is utilized as a building block in organic chemistry, allowing for the creation of a variety of organic compounds. Its structural attributes facilitate its use in the synthesis of complex organic molecules for diverse applications.

InChI:InChI=1/C12H14N2S/c1-8(2)9-3-5-10(6-4-9)11-7-15-12(13)14-11/h3-8H,1-2H3,(H2,13,14)

Upstream product

• 51012-62-5 α-bromomethyl 4-isopropylphenyl ketone 
• 17356-08-0 thiourea 
• 645-13-6 4-isopropylacetophenone 
• 2103-94-8 4-(4-bromophenyl)-1,3-thiazol-2-amine 

Downstream Products

• 1400283-75-1 C₂₅H₂₉N₃O₃S₂ 
• 109943-23-9 sulfanilic acid-[4-(4-isopropyl-phenyl)-thiazol-2-ylamide] 
• 112657-58-6 N-acetyl-sulfanilic acid-[4-(4-isopropyl-phenyl)-thiazol-2-ylamide] 

Relevant academic research and scientific papers

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

Carbon tetrabromide mediated oxidative cyclocondensation of ketones and thioureas: An easy access to 2-aminothiazoles

A simple, mild, and efficient one-pot method for the synthesis of substituted 2-aminothiazoles has been reported. The reaction involves the formation of sulfenyl bromide as an umpolung intermediate of nucleophilic sulfur, which is responsible for C-S bond formation leading to oxidative cyclization of ketones and thioureas to furnish the desired products. Carbon tetrabromide was used as a convenient and mild brominating reagent under basic condition at room temperature to give 2-aminothiazoles in good to excellent yields.

Stereoretentive Pd-catalysed Stille cross-coupling reactions of secondary alkyl azastannatranes and aryl halides

The development of transition metal-catalysed cross-coupling reactions has greatly influenced the manner in which the synthesis of complex organic molecules is approached. A wide variety of methods are now available for the formation of C(sp2)-C(sp2) bonds, and more recent work has focused on the use of C(sp3) electrophiles and nucleophiles. The use of secondary and tertiary alkyl nucleophiles in cross-coupling reactions remains a challenge because of the propensity of these alkyl groups to isomerize under the reaction conditions. Here, we report the development of a general Pd-catalysed process for the stereoretentive cross-coupling of secondary alkyl azastannatrane nucleophiles with aryl chlorides, bromides, iodides and triflates. Coupling partners with a wide range of electronic characteristics are well tolerated. The reaction occurs with minimal isomerization of the secondary alkyltin nucleophile, and with retention of absolute configuration. This process constitutes the first general method to use secondary alkyltin reagents in cross-coupling reactions.

QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS

The present invention provides Quinazolinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by T

SUBSTITUTED THIAZOLE AND PYRIMIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS

The present invention provides substituted thiazole and pyrimidine derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.