108482-18-4

Basic information

• Product Name: ethyl 2-(3-(4-methoxyphenyl)ureido)acetate
• Synonyms: ethyl 2-(3-(4-methoxyphenyl)ureido)acetate
• CAS NO: 108482-18-4
• Molecular Weight: 252.27
• Mol File: 108482-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(3-(4-methoxyphenyl)ureido)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3-(4-methoxyphenyl)ureido)acetate(108482-18-4)
• EPA Substance Registry System: ethyl 2-(3-(4-methoxyphenyl)ureido)acetate(108482-18-4)

Safety Data

• Hazardous Substances Data: 108482-18-4(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 2949-22-6 Glycine ethyl ester isocyanate 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 623-33-6 glycine ethyl ester hydrochloride 

Downstream Products

• 62101-55-7 3-(4-methoxyphenyl)imidazolidine-2,4-dione 

Relevant articles and documents

Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors

Based on the structure of HIV-1 gp41 binding site for small-molecule inhibitors, optimization of lead 2 resulted in the discovery of a new series of 2,5-dimethyl-3-(5-(N-phenylrhodaninyl)methylene)-N-(3-(1H-tetrazol-5-yl)phenyl) pyrrole compounds with improved anti-HIV-1 activity. The most active compounds 13a and 13j exhibited significant potency against gp41 6-HB formation with IC50 values of 4.4 and 4.6 μM and against HIV-1 replication in the MT-2 cells with EC50 values of 3.2 and 2.2 μM, respectively, thus providing a new starting point to develop highly potent small-molecule HIV fusion inhibitors targeting gp41.