1084909-67-0Relevant academic research and scientific papers
Synthesis of β-lactams bearing functionalized side chains from a readily available precursor
Lee, Myung-Ryul,Stahl, Shannon S.,Gellman, Samuel
supporting information; experimental part, p. 5317 - 5319 (2009/06/18)
(Chemical Equation Presented) The reaction of chlorosulfonyl isocyanate (CSI) with alkenes provides β-lactams in quantity, and the products have frequently been used for ring-opening polymerization to generate nylon-3 materials. Prior uses of this approach have focused almost entirely on β-lactams with purely hydrocarbon substitutents. We show how a variety of β-lactams bearing protected polar substituents can be generated from CSI-derived building blocks.
