108530-05-8Relevant academic research and scientific papers
Synthesis of functionalized polycyclic aromatic compounds via a formal [2 + 2]-cycloaddition
Nagamoto, Yuuki,Yamaoka, Yousuke,Fujimura, Shun,Takemoto, Yoshiji,Takasu, Kiyosei
supporting information, p. 1008 - 1011 (2014/03/21)
A base-promoted formal [2 + 2]-cycloaddition of 2-acyl-2′-vinyl-1, 1′-biaryls was developed to provide polycyclic cyclobutanols as a step toward the synthesis of substituted polycyclic aromatic hydrocarbons and their heterocyclic analogues.
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators
Ortar, Giorgio,Schiano Moriello, Aniello,Morera, Enrico,Nalli, Marianna,Di Marzo, Vincenzo,De Petrocellis, Luciano
, p. 5614 - 5618 (2013/10/01)
Following the recent identification of the naturally occurring 3-ylidene-4,5-dihydrophthalide ligustilide and its oxidation product dehydroligustilide as novel TRPA1 modulators, a series of seventeen 3-ylidenephthalides was synthesized and tested on TRPA1 and TRPM8 channels. Most of these compounds acted as strong modulators of the two channel types with EC50 and/or IC50 values distinctly lower than those of the reference compounds.
Titanocene-catalyzed cyclocarbonylation of o-allyl aryl ketones to γ- butyrolactones
Kablaoui, Natasha M.,Hicks, Frederick A.,Buchwald, Stephen L.
, p. 4424 - 4431 (2007/10/03)
A method for the transformation of o-allyl aryl ketones to γ- butyrolactones using a catalytic amount of Cp2Ti(PMe3)2 or Cp2Ti(CO)2 iS described. This catalytic 'hetero Pauson-Khand'-type process proc
A new synthesis of 3-ylidenephthalides via palladium-catalyzed cyclocarbonylation of 2-triflyloxyacetophenones
Ciattini,Mastropietro,Morera,Ortar
, p. 3763 - 3766 (2007/10/02)
The reaction of 2-triflyloxyacetophenone derivatives 1 with carbon monoxide in the presence of a palladium catalyst affords 3-ylidenephthalides 2 in good yields and under mild conditions.
