1085313-37-6Relevant articles and documents
Syntheses of a selective peroxisome proliferator activated receptor modulator and practical new preparations of 2-(4-Alkoxyphenyl) ethylamines t
Magnus, Nicholas A.,Astleford, Bret A.,Brennan, John,Stout, James R.,Tharp-Taylor, Roger W.
experimental part, p. 280 - 284 (2010/04/22)
This article describes chemistry that was developed to give access to multigram quantities of the selective peroxisome proliferator activated receptor modulator (SPPARM), compound 1.1 Fischer esteriflcations, phase transfer-catalyzed alkylations, amide couplings, crystallizations, and a new synthesis were developed to accomplish this task. In addition, an efficient method for preparing 2-(4-alkoxyphenyl) ethylamines 7a - d from tyramine 9 was developed that involves O-alkylation of intermediate Schiff base 11 and subsequent acid-catalyzed hydrolysis to afford the target molecules as crystalline hydrochloride salts.
