1085339-66-7Relevant academic research and scientific papers
Combinatorial synthesis of the 1,5-polyol system based on cross metathesis: Structure revision of amphidinol 3
Oishi, Tohru,Kanemoto, Mitsunori,Swasono, Respati,Matsumori, Nobuaki,Murata, Michio
, p. 5203 - 5206 (2008)
(Chemical Equation Presented) Combinatorial synthesis of a 1,5-polyol system corresponding to the C1-C14 unit of amphidinol 3 (AM3) and its diastereomers was achieved via chemoselective cross metathesis as the key step. Comparison of 13C NMR data of the synthetic specimens with that of AM3 led to a controversy regarding the originally proposed structure. From GC-MS analysis of the degradation product, the absolute configuration at C2 of AM3 has been revised to be R.
