108535-38-2

Upstream product

• 108535-35-9 (R)-(+)-(2-hydroxy-3,3,3-trifluoropropyl)phenyl ketone 
• 116316-21-3 Acetic acid 3-oxo-3-phenyl-1-trifluoromethyl-propyl ester 
• 1524-15-8 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 
• 108560-80-1 (R)-4,4,4-Trifluoro-1-phenyl-3-(tetrahydro-pyran-2-yloxy)-butan-1-ol 

Relevant academic research and scientific papers

Asymmetric chemoenzymatic synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes by using whole cell biocatalysts

Regio- and stereo-selective reduction of substituted 1,3-aryldiketones, investigated in the presence of different whole cell microorganisms, was found to afford β-hydroxyketones or 1,3-diols in very good yields (up to 95%) and enantiomeric excesses (up to 96%). The enantiomerically enriched aldols, obtained with the opposite stereo-preference by baker's yeast and Lactobacillus reuteri DSM 20016 bioreduction, could then be diastereoselectively transformed into optically active syn- or anti-1,3-diols by a careful choice of the chemical reducing agent (diastereomeric ratio up to 98 : 2). The latter, in turn, were stereospecifically cyclized into the corresponding oxetanes in 43-98% yields and in up to 94% ee, thereby giving a diverse selection of stereo-defined 2,4-disubstituted aryloxetanes.

A Microbially Based Approach for the Preparation of Chiral Molecules Possessing the Trifluoromethyl Group

The synthetic approach to both enantiomers and diastereomers with the trifluoromethyl group, involving the stereoselective hydrolysis of the ester group and acyclic stereoselection, is described.The absolute configuration of these trifluoromethylated mole