1085399-11-6

Basic information

• Product Name: C₂₀H₁₇IN₂O₃
• Synonyms: C₂₀H₁₇IN₂O₃
• CAS NO: 1085399-11-6
• Molecular Weight: 460.271
• Mol File: 1085399-11-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇IN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇IN₂O₃(1085399-11-6)
• EPA Substance Registry System: C₂₀H₁₇IN₂O₃(1085399-11-6)

Safety Data

• Hazardous Substances Data: 1085399-11-6(Hazardous Substances Data)

Upstream product

• 54907-61-8 iodoacetic anhydride 
• 1085399-09-2 C₁₈H₁₆N₂O₂ 

Downstream Products

• 1085399-07-0 C₂₆H₃₂N₃O₃⁽¹⁺⁾*I^(1-) 

Relevant articles and documents

An activity-based protein profiling probe for the nicotinic acetylcholine receptor

Activity-based protein profiling (ABPP) has been used extensively to characterize the physiological functions of enzymes but has not yet been extended to ion channels. We have synthesized a state-dependent photoaffinity probe for the nicotinic acetylcholine receptor (nAChR) as a proof of concept for the development of ion channel directed ABPP probes. The candidate probe BPyneTEA comprises an nAChR binding moiety, a benzophenone moiety for photolabeling, and an alkyne moiety for biotinylation via click chemistry . Single-molecule current measurements show that BPyneTEA blocks both the closed and open (i.e., nondesensitized) conformations of the nAChR with similar kinetics. In living cells, BPyneTEA photolabels the closed state selectively over the inactive desensitized state. BPyneTEA thus shows promise as a probe for nondesensitized nAChRs and may be useful in studying the molecular physiology of desensitization. The structure and reactivity of ion channel pores in general suggest that they will be a broadly useful target for ABPP probes. Copyright