1085446-39-4Relevant academic research and scientific papers
Antiviral Agents
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Page/Page column 15-16, (2010/06/22)
A compound of formula (I) and pharmaceutically acceptable salts thereof; compositions containing it and its use in medicine, particularly for the treatment or inhibition of HCV infections, and processes for making it are disclosed.
Phosphoramidate prodrugs of 2′-C-methylcytidine for therapy of hepatitis C virus infection
Gardelli, Cristina,Attenni, Barbara,Donghi, Monica,Meppen, Malte,Pacini, Barbara,Harper, Steven,Di Marco, Annalise,Fiore, Fabrizio,Giuliano, Claudio,Pucci, Vincenzo,Laufer, Ralph,Gennari, Nadia,Marcucci, Isabella,Leone, Joseph F.,Olsen, David B.,MacCoss, Malcolm,Rowley, Michael,Narjes, Frank
experimental part, p. 5394 - 5407 (2010/04/30)
The application of a phosphoramidate prodrug approach to 2′-C-methylcytidine (NM107), the first nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, is reported. 2′-C-Methylcytidine, as its valyl ester prodrug (NM283), was efficacious in r
