1085708-91-3

Basic information

• Product Name: 1-(3-methoxy-4-hydroxyphenyl)-3-(2-methylthio-1,3,4-oxadiazol-5-yl) β-carboline
• Synonyms: 1-(3-methoxy-4-hydroxyphenyl)-3-(2-methylthio-1,3,4-oxadiazol-5-yl) β-carboline
• CAS NO: 1085708-91-3
• Molecular Weight: 404.449
• Mol File: 1085708-91-3.mol

Chemical Properties

• CAS DataBase Reference: 1-(3-methoxy-4-hydroxyphenyl)-3-(2-methylthio-1,3,4-oxadiazol-5-yl) β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-methoxy-4-hydroxyphenyl)-3-(2-methylthio-1,3,4-oxadiazol-5-yl) β-carboline(1085708-91-3)
• EPA Substance Registry System: 1-(3-methoxy-4-hydroxyphenyl)-3-(2-methylthio-1,3,4-oxadiazol-5-yl) β-carboline(1085708-91-3)

Safety Data

• Hazardous Substances Data: 1085708-91-3(Hazardous Substances Data)

Upstream product

• 1085708-82-2 1-(3-methoxy-4-hydroxyphenyl)-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carboline 
• 74-88-4 methyl iodide 

Relevant articles and documents

Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) β-carboline derivatives

Several novel 1-substituted-phenyl β-carbolines bearing the 2-substituted-1,3,4-oxadiazol-5-yl and 5-substituted-1,2,4-triazol-3-yl groups at C-3 were synthesized and evaluated for their in vitro anticancer activity. The assay results pointed thirteen compounds with growth inhibition effect (GI50 50 values lying in the nanomolar concentration range (GI50 = 10 nM for both compounds). The 1-(N,N-dimethylaminophenyl)-3-(5-thioxo-1,2,4-triazol-3-yl) β-carboline (8g) was the most active compound, showing particular effectiveness on lung (GI50 = 0.06 μM), ovarian and renal cell lines. The potent anticancer activity presented for synthesized compounds 7a, 7h, and 8g, together with their easiness of synthesis, makes these compounds promising anticancer agents.