1085709-07-4

Upstream product

• 799821-64-0 methyl 1-(4-hydroxyphenyl)-β-carboline-3-carboxylate 
• 1392197-71-5 C₁₈H₁₂N₂O₃ 
• 123-08-0 4-hydroxy-benzaldehyde 
• 73-22-3 L-Tryptophan 

Downstream Products

• 1085708-78-6 1-(4-hydroxyphenyl)-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carboline 
• 1085708-96-8 1-(4-hydroxyphenyl)-3-(5-thioxo-1,2,4-triazol-3-yl) β-carboline 
• 1345667-75-5 N'-cyclopentylidene-1-(4-hydroxyphenyl)-β-carboline-3-carbohydrazide 
• 1198097-64-1 1-(4-hydroxyphenyl)-N'-(4-N,N-dimethylaminobenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide 
• 1198097-63-0 1-(4-hydroxyphenyl)-N'-(4-methoxybenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide 
• 1198097-65-2 1-(4-hydroxyphenyl)-N'-(benzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide 
• 1198097-66-3 1-(4-hydroxyphenyl)-N'-(4-nitrobenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide 
• 1198097-67-4 1-(4-hydroxyphenyl)-N'-(2-chlorobenzylidene)-9H-pyrido[3,4-b]indole-3-carbohydrazide 

Relevant academic research and scientific papers

Synthesis and antitumor activity of β-carboline 3-(substituted- carbohydrazide) derivatives

A series of β-carboline derivatives bearing a substituted- carbohydrazide moiety at C-3 were synthesized and evaluated for their antitumor activity against eight human cancer cell lines. The b-carboline N-(substituted-benzylidene)carbohydrazides showed, i

Synthesis and antiviral activity of β-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1)

Several novel 1,3-disubstituted β-carboline derivatives bearing a substituted carbohydrazide group at C-3 were synthesized and evaluated for their antiviral activity against vaccinal poliovirus (VP) and herpes simplex virus type 1 (HSV-1). The cytotoxicity and selectivity index of the active compounds were also evaluated. Among the synthesized derivatives, compounds 10 and 11 displayed potent activity against both vaccinal poliovirus and HSV-1 virus. Compound 10 presented the highest selectivity index (SI = 2446.8) against HSV-1 virus and low cytotoxicity (CC50 = 1150.0 ± 67.3 μM). The virus yield inhibition assay showed that compound 10 was able to inhibit HSV-1 plaque formation before and during the virus adsorption. The characteristic small plaque pattern observed in compound-treated cells suggested that compound 10 inhibited viral dissemination to neighboring cells. A computational study for prediction of ADME properties of the novel synthesized β-carbolines derivatives was performed by determination of lipophilicity, topological polar surface area (TPSA), absorption (% ABS) and simple molecular descriptors, using Lipinski′s rule.

Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) β-carboline derivatives

Several novel 1-substituted-phenyl β-carbolines bearing the 2-substituted-1,3,4-oxadiazol-5-yl and 5-substituted-1,2,4-triazol-3-yl groups at C-3 were synthesized and evaluated for their in vitro anticancer activity. The assay results pointed thirteen compounds with growth inhibition effect (GI50 50 values lying in the nanomolar concentration range (GI50 = 10 nM for both compounds). The 1-(N,N-dimethylaminophenyl)-3-(5-thioxo-1,2,4-triazol-3-yl) β-carboline (8g) was the most active compound, showing particular effectiveness on lung (GI50 = 0.06 μM), ovarian and renal cell lines. The potent anticancer activity presented for synthesized compounds 7a, 7h, and 8g, together with their easiness of synthesis, makes these compounds promising anticancer agents.