1085841-72-0Relevant academic research and scientific papers
Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes
Qian, Yimin,Wertheimer, Stanley J.,Ahmad, Mushtaq,Cheung, Adrian Wai-Hing,Firooznia, Fariborz,Hamilton, Matthew M.,Hayden, Stuart,Li, Shiming,Marcopulos, Nicholas,McDermott, Lee,Tan, Jenny,Yun, Weiya,Guo, Liang,Pamidimukkala, Anjula,Chen, Yingsi,Huang, Kuo-Sen,Ramsey, Gwendolyn B.,Whittard, Toni,Conde-Knape, Karin,Taub, Rebecca,Rondinone, Cristina M.,Tilley, Jefferson,Bolin, David
experimental part, p. 2433 - 2446 (2011/06/17)
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain on hig
DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
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, (2009/01/20)
Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
