1085853-16-2Relevant academic research and scientific papers
Synthetic utility of ammonium salts in a Cu-catalyzed three-component reaction as a facile coupling partner
Kim, Jinho,Lee, S. Yunmi,Lee, Junseung,Do, Youngkyu,Chang, Sukbok
supporting information; experimental part, p. 9454 - 9457 (2009/04/06)
(Chemical Equation Presented) Ammonium salts were found to be a convenient and inexpensive reagent in the Cu-catalyzed three-component reaction with terminal alkynes and sulfonyl or phosphoryl azides leading to N-unprotected amidines. Thus obtained amidines bearing 2-bromobenzenesulfonyl moiety were efficiently cyclized by the Cu-catalyzed intramolecular N-arylation to give an important pharmacophore skeleton of 2H-1,2,4-benzothiadiazine 1,1-dioxides. Conveniently, two tandem catalytic procedures could be readily operated in one pot.
