108587-10-6

Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-Norbornane-dicarbonitrile-(2endo.3exo) is used as a versatile building block for the synthesis of pharmaceuticals. Its unique structure allows for the development of new drugs with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (+/-)-norbornane-dicarbonitrile-(2endo.3exo) is utilized as a key intermediate in the production of agrochemicals. Its reactivity and structural properties contribute to the creation of effective pesticides, herbicides, and other agricultural chemicals.
Used in Advanced Materials:
(+/-)-Norbornane-dicarbonitrile-(2endo.3exo) is employed as a component in the development of advanced materials. Its unique structure and properties make it suitable for use in the creation of high-performance materials for various applications, such as coatings, adhesives, and composites.
Used in Organic Electronics and Materials Science:
(+/-)-Norbornane-dicarbonitrile-(2endo.3exo) has potential applications in the field of organic electronics and materials science. Its unique structure and reactivity can be harnessed to develop new materials with improved electronic properties, such as conductive polymers and organic semiconductors, which can be used in various electronic devices and technologies.

Upstream product

• 6343-16-4 bicyclo<2.2.1>hept-5,6-ene-2α,3β-dicarbonitrile 

Downstream Products

• 73679-39-7 anti-1,2,3,4,5,6,7,8-octahydro-1,4,5,8-dimethano-naphthalene anti-sesquinorbornene 
• 7399-32-8 2,3-dicyanobicyclo[2,2,1]hept-2-ene 

Relevant academic research and scientific papers

Synthesis, biophysical studies, and antiproliferative activity of platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands

A selected chemical library of six platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands were synthesized after a rational design in order to evaluate their antiproliferative activity and the structure-activity relationships. The cytotoxicity studies were performed using cancer cell lines sensitive (A2780) and resistant (A2780R) to cisplatin. Excellent cytotoxicity was observed for most of complexes, which presented better resistance factors than cisplatin against the A2780R cell line. The interaction of these complexes with DNA, as the target biomolecule, was evaluated by several methods: DNA-platinum binding kinetics, changes in the DNA melting temperature, evaluation of the unwinding angle of supercoiled DNA, evaluation of the interstrand cross-links, and replication mapping. The kinetics of the interaction with glutathione was also investigated to better understand the resistant factors observed for the new complexes.

SYNTHESIS OF anti-SESQUINORBORNENE AND RELATED POLYCYCLIC ALKENES via REDUCTIVE ELIMINATION OF VICINAL DICYANO DERIVATIVES

A methodology for the preparation of both endocyclic unsaturated molecules via reductive elimination of vicinal dicyano derivatives is reported.The method is useful for the preparation of anti-sesquinorbornene and related hitherto unknown molecules starting from the respective vicinal dicyano derivatives which are readily available via Diels-Alder reactions.From a practical point of view, the best decyanation procedure for these substrates is to use finely dispersed sodium in tetrahydrofuran under sonication.The X-ray analysis of anti-1,4,4a,5,8,8a-hexahydro-1,4;5,8-dimethanonaphthalene-4a,8a-dicarbonitrile, 3, is reported.Crystal data: orthorhombic, space group P212121; Z=4; a=16.059(5), b=8.920(3), c=7.592(3) Angstroem; V=1087.5 Angstroem3, Dc=1.27 g*cm-3.