108590-52-9

Basic information

• Product Name: 2-(4'-methylbenzenesulfonyl)-L-glutamic acid dichloride
• Synonyms: 2-(4'-methylbenzenesulfonyl)-L-glutamic acid dichloride
• CAS NO: 108590-52-9
• Molecular Weight: 338.212
• Mol File: 108590-52-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4'-methylbenzenesulfonyl)-L-glutamic acid dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-methylbenzenesulfonyl)-L-glutamic acid dichloride(108590-52-9)
• EPA Substance Registry System: 2-(4'-methylbenzenesulfonyl)-L-glutamic acid dichloride(108590-52-9)

Safety Data

• Hazardous Substances Data: 108590-52-9(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 56-86-0 L-glutamic acid 
• 4816-80-2 N-tosyl-L-glutamic acid 

Downstream Products

• 103034-47-5 1,5-N,N'-di-cyclohexyl-2-(4'-methylbenzenesulfonyl)glutamamide 
• 104398-41-6 5-oxo-1-(toluene-4-sulfonyl)-L-proline amide 
• 6304-81-0 N-[(4-methylphenyl)sulfonyl]-L-glutamic acid-1,5-diethyl ester 

Relevant articles and documents

Syntheses, biological evaluation and QSAR study on antitumor activity of 1,5-N,N′-disubstituted-2-(substituted benzenesulphonyl) glutamamides

We have reported [unpublished data] the synthesis and QSAR of 5-substituted-2-(substituted benzenesulphonyl) glutamines which have shown the importance of steric factor on the aliphatic chain. N-Phthalyl isoglutamine, having the substitution at position 1 of the glutamic acid moiety, is the metabolite of recently approved thalidomide for different types of tumors by US FDA. Based on these, 36 new 1,5-N,N′-disubstituted-2-(substituted benzenesulphonyl) glutamamides were synthesized, as tools for further elucidation of the structural requirements for antitumor activity. All the synthesized compounds were tested for antitumor activity against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice using tumor weight as inhibitory parameter. Quantitative structure-activity relationship (QSAR) studies of these analogues revealed that the electron donating groups on the phenyl ring are found to be mandatory for the activity which was also proved by the negative coefficient of indicator parameter I3, for NO2 group on the phenyl ring. Molecular volume (MV) and steric factor at R5 position also plays a role in ligand-receptor interactions.