1086006-89-4Relevant academic research and scientific papers
Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
Niswender, Colleen M.,Lebois, Evan P.,Luo, Qingwei,Kim, Kwangho,Muchalski, Hubert,Yin, Huiyong,Conn, P. Jeffrey,Lindsley, Craig W.
experimental part, p. 5626 - 5630 (2009/07/18)
This letter describes the synthesis and SAR, developed through an iterative analogue library approach, of an mGluR4 positive allosteric modulator lead based on a pyrazolo[3,4-d]pyrimidine scaffold. Despite tremendous therapeutic potential, Compound 7, VU0080421, and related congeners represent only a handful of mGluR4 positive allosteric modulators ever described.
