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High quality teriflunomide supplier in China
Cas No: 108605-62-5
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Teriflunomide CAS NO.108605-62-5
Cas No: 108605-62-5
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Large Stock 99.0% A77 1726 108605-62-5 Producer
Cas No: 108605-62-5
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Cas No: 108605-62-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
TIANFU CHEM----A77 1726
Cas No: 108605-62-5
No Data 1 Kilogram 10 Metric Ton/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 108605-62-5 with competitive price
Cas No: 108605-62-5
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
teriflunomide CAS:108605-62-5 Safe delivery Free of customs clearance
Cas No: 108605-62-5
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
BLOOM TECH Advanced API/Technology support 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide CAS 108605-62-5
Cas No: 108605-62-5
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide factory price
Cas No: 108605-62-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Hangzhou Sartort Biopharma Co., Ltd Contact Supplier
2-Butenamide,2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- 108605-62-5
Cas No: 108605-62-5
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier

108605-62-5 Usage


Teriflunomide (Aubagio?), also known as A77 1726, is an immunosupressant marketed by Sanofi for the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced B and T cell proliferation.

Chemical Properties

White Solid


The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.

Clinical Use

Immunomodulating agent: Treatment of relapsing remitting multiple sclerosis


Numerous syntheses of teriflunomide have been developed to date, most relying on the use of 4- trifluoromethyl aniline (167). The current optimized method for scale-up synthesis of teriflunomide, developed by Keshav and coworkers, begins with reaction of commercial 4-trifluoromethyl aniline 167 and ethylacetoacetate (168) in refluxing xylenes, providing acetoamidate 169 in 51% yield . The resulting acetoamidate 169 was then treated with H2O2, KBr, and concentrated HCl at room temperature, providing bromide 170 in 67% yield. Bromide 170 was reacted with NaCN in DMSO, generating teriflunomide (XXVI) in 85% yield.

Drug interactions

Potentially hazardous interactions with other drugs Lipid-lowering agents: effect significantly reduced by colestyramine - avoid; concentration of rosuvastatin increased - consider reducing rosuvastatin dose. Live vaccines: risk of generalised infections - avoid.


Teriflunomide is the active metabolite of leflunomide. It is moderately metabolised and teriflunomide is the only component detected in plasma. The main biotransformation pathway is hydrolysis with oxidation being a minor pathway. Secondary pathways involve oxidation, N-acetylation and sulfate conjugation. Teriflunomide is excreted in the gastrointestinal tract mainly through the bile as unchanged drug and most likely by direct secretion.


1) Manna et al. (1999), Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression; J. Immunol., 162 2095 2) Davis et al. (1996), immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270 3) Seah et al. (2008), Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726; Drug Metab. Lett., 2 153

Check Digit Verification of cas no

The CAS Registry Mumber 108605-62-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,6,0 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 108605-62:
115 % 10 = 5
So 108605-62-5 is a valid CAS Registry Number.

108605-62-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1357056)  Leflunomide Related Compound B  United States Pharmacopeia (USP) Reference Standard 108605-62-5 1357056-20MG 19,925.10CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide

1.2 Other means of identification

Product number -
Other names 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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