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1086063-46-8

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1086063-46-8 Usage

General Description

N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide is a chemical compound with the molecular formula C11H8BrF2N2O3S. It is a derivative of benzenesulfonamide, containing a bromo-substituted pyridine ring and two fluorine atoms. N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide has potential applications in pharmaceuticals and agrochemicals due to its unique structure and potential biological activity. It is often used as a building block in the synthesis of various heterocyclic compounds and has the potential for further development as a drug candidate or as a chemical intermediate in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 1086063-46-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,6,0,6 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1086063-46:
(9*1)+(8*0)+(7*8)+(6*6)+(5*0)+(4*6)+(3*3)+(2*4)+(1*6)=148
148 % 10 = 8
So 1086063-46-8 is a valid CAS Registry Number.

1086063-46-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(5-Bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

1.2 Other means of identification

Product number -
Other names N-(5-bromo-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1086063-46-8 SDS

1086063-46-8Relevant articles and documents

Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation

Chen, Yi,Deng, Mingli,Jia, Yu,Ling, Yun,Liu, Xiaofeng,Lu, Mingzhu,Qiu, Tianze,Xiang, Ruiqing,Yang, Chengbin,Yang, Yongtai,Zhou, Yaming

supporting information, (2021/10/19)

Breast cancer is the cancer with the highest incidence all over the world. Phosphatidylinositol 3-kinase is an important regulator of intracellular signaling pathways, which is frequently mutated and overexpressed in majority of human breast cancers, and the inhibition of PI3K has been considered as a promising approach for the treatment of the cancer. Here, we report our design and synthesis of new 7-azaindole derivatives as PI3K inhibitors through the scaffold hopping strategy. By varying the groups at the 3-position of 7-azaindole, we identified a series of potent PI3K inhibitors, whose antiproliferative activities against two human breast cancer MCF-7 and MDA-MB-231 cell lines were evaluated. Representative derivatives FD2054 and FD2078 showed better activity than BKM120 in antiproliferation, reduced the levels of phospho-AKT and induced cell apoptosis. All these results suggested that FD2054 and FD2078 are potent PI3K inhibitors that could be considered as potential candidates for the development of anticancer agents.

PI3K/mTOR protein degradation targeting chimeric compound as well as preparation method and medical application of PI3K/mTOR protein degradation targeting chimeric compound

-

Paragraph 0244; 0247; 0250-0251, (2021/02/10)

The invention relates to a PI3K/mTOR protein degradation targeting chimeric body (PROTAC) compound as well as a preparation method and medical application thereof. Specifically, the present inventionrelates to a compound represented by a general formula (

FIBROBLAST ACTIVATION PROTEIN (FAP) TARGETED IMAGING AND THERAPY IN FIBROSIS

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Page/Page column 22, (2020/05/21)

Excessive deposition of extracellular matrix is a hallmark of Idiopathic pulmonary fibrosis (IPF), it is advantageous to target the cells and the mechanisms associated with this process. By targeting myofibroblasts (specialized contractile fibroblasts) th

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