108618-52-6Relevant academic research and scientific papers
A novel method for heterocyclic amide-thioamide transformations
Fathalla, Walid,Ali, Ibrahim A. I.,Pazdera, Pavel
, p. 174 - 181 (2017/02/15)
In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.
